Cotuit Center for the Arts and WatermelonAlligator Theatre Company will present the New England regional premiere of “Lopsided,” a play by E.A. Kafkalas, from October 10 through 27 in the Black Box Theater. Performances are Thursday through Saturday at 7:30 PM, and Sunday at 2 PM.

How long, and how tight, should you hold on to a part of yourself that’s no longer there? It’s the most wrenching question in Ms. Kafkalas’s searching drama. The play explores the raw side of breast cancer, from the scars of surgery to the damaged self-image. At the same time, it embraces a sense of strength and hope, reminding the audience that the membrane between being shallow and being human is paper thin.

Four college friends have reunited in London for the marriage of their friend, Dr. Mary Lewis. Megan, a photographer, discovers her best friend, Laurie, a high school teacher, has been fighting breast cancer for the past seven months. Laurie kept her illness a secret from Megan because Megan lost her lover to inflammatory breast cancer. Despite Laurie’s positive attitude, her self esteem has been shattered by the mastectomy and her ex-boyfriend’s insensitivity. Complicating Laurie’s weekend is the thought of seeing Gail, who still believes Laurie stole her boyfriend in college.

The cast includes Julie Butler of Pembroke, Ian Rubinstein of Bourne, Susan Salvesen of Marion, Victoria Smith of Mashpee and Jess Wilson of Onset, who also appeared in the world premiere of “Lopsided.” The production will be stage managed by Annie Rossi of Wareham.

Tickets are $20, $15 for members. Cotuit Center for the Arts is at 4404 Route 28.

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